.png)
- CasNo 189028-93-1
- Purity 99%
Location:Home > Pharmaceutical
(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone
(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone Good Supplier In Bulk Supply High Purity 189028-93-1
- Molecular Formula: C20H18FNO4
- Molecular Weight: 355.366
- Vapor Pressure: 6.19E-13mmHg at 25°C
- Melting Point: 90.0 to 94.0 °C
- Refractive Index: 1.578
- Boiling Point: 568.4 °C at 760 mmHg
- PKA: -3.11±0.40(Predicted)
- Flash Point: 297.6 °C
- PSA： 63.68000
- Density: 1.288 g/cm3
- LogP: 3.83670
(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone(Cas 189028-93-1) Usage
InChI:InChI=1/C20H18FNO4/c21-16-11-9-15(10-12-16)18(23)7-4-8-19(24)22-17(13-26-20(22)25)14-5-2-1-3-6-14/h1-3,5-6,9-12,17H,4,7-8,13H2/t17-/m1/s1
189028-93-1 Relevant articles
Ezetimibe intermediate and preparation method of ezetimibe
-
Paragraph 0098-0099, (2020/08/27)
The invention relates to an ezetimibe in...
Ezetimibe intermediate, synthesis method of intermediate and synthesis method of ezetimibe
-
Paragraph 0053; 0086; 0087, (2017/07/01)
The invention provides an ezetimibe inte...
according to folds Mai Bu and its intermediate synthesis method
-
Paragraph 0063; 0064; 0065; 0066, (2017/07/26)
The invention provides an Ezetimibe synt...
Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe
Zhu, Yijun,Pan, Jing,Zhang, Shunli,Liu, Zhenren,Ye, Deyong,Zhou, Weicheng
supporting information, p. 1687 - 1693 (2016/10/21)
An efficient and scalable process for th...
189028-93-1 Process route
-
-
99395-88-7,7480-32-2
(S)-4-phenyl-2-oxazolidinone
-
-
149437-76-3
5-(4-fluorophenyl)-5-oxopentanoic acid
-
-
189028-93-1,404874-93-7
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
Conditions
| Conditions | Yield |
|---|---|
|
With
dmap; dicyclohexyl-carbodiimide;
In
dichloromethane;
|
86%
|
|
5-(4-fluorophenyl)-5-oxopentanoic acid;
With
dmap; pivaloyl chloride;
In
N,N-dimethyl-formamide;
at 2 - 20 ℃;
for 1.5h;
(S)-4-phenyl-2-oxazolidinone;
In
N,N-dimethyl-formamide;
at 30 - 35 ℃;
for 2h;
|
85.7%
|
|
5-(4-fluorophenyl)-5-oxopentanoic acid;
With
pivaloyl chloride; triethylamine;
In
tetrahydrofuran;
at -10 ℃;
for 4h;
Inert atmosphere;
(S)-4-phenyl-2-oxazolidinone;
With
lithium chloride;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
Inert atmosphere;
|
85%
|
|
5-(4-fluorophenyl)-5-oxopentanoic acid;
With
pivaloyl chloride; triethylamine;
In
dichloromethane;
(S)-4-phenyl-2-oxazolidinone;
With
dmap;
In
dichloromethane; N,N-dimethyl-formamide;
for 13h;
Reflux;
|
70%
|
|
5-(4-fluorophenyl)-5-oxopentanoic acid;
With
pivaloyl chloride; triethylamine;
In
dichloromethane;
at 5 - 10 ℃;
for 2.5h;
(S)-4-phenyl-2-oxazolidinone;
With
dmap;
In
dichloromethane; N,N-dimethyl-formamide;
at 15 - 45 ℃;
for 3h;
|
68%
|
|
5-(4-fluorophenyl)-5-oxopentanoic acid;
With
oxalyl dichloride;
In
dichloromethane;
at -10 ℃;
for 0.5h;
(S)-4-phenyl-2-oxazolidinone;
With
triethylamine;
In
toluene;
at 75 ℃;
|
-
![(4S)-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one](/upload/2026/6/14fee33105aa45fdb110662579d7301d_e1739f8b-7a2c-4332-9ae2-c2bd877943f3.png)
-
528565-93-7
(4S)-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
-
-
189028-93-1,404874-93-7
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
Conditions
| Conditions | Yield |
|---|---|
|
With
pyridinium chlorochromate;
In
dichloromethane;
at 40 ℃;
for 2h;
|
91%
|
189028-93-1 Upstream products
-
1056188-47-6
C16 H19 FO4
-
99395-88-7
(S)-4-phenyl-2-oxazolidinone
-
3282-30-2
pivaloyl chloride
-
149437-76-3
5-(4-fluorophenyl)-5-oxopentanoic acid
189028-93-1 Downstream products
-
189028-95-3
(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
-
528565-93-7
(4S)-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
-
953805-20-4
3-{4-[2-(4-fluorophenyl)-5,5-dimethyl-[1,3]dioxin-2-yl]butyryl}(4S)-phenyl-1,3-oxazolidin-2-one
-
438624-68-1
1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-([12C6 ]-4-hydroxyphenyl)-2-azetidinone
WANT TO PURCHASE
Please contact us and we will reply to you as soon as possible.
