What is the Ponatinib?

Ponatinib is , while it's Molecular Formula is C 29 H 27 F 3 N 6 O. Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRa, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively

What is the CAS number for Ponatinib?

The CAS number of Ponatinib is 943319-70-8.

What is Ponatinib (943319-70-8) used for?

Ponatinib (943319-70-8) is a highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well as the mutants T315I (IC50=2 nM), Q252H (IC50=0.44 nM), Y253F (IC50=0.3 nM), M351T (IC50=0.3 nM) and H396P (IC50=0.34 nM).1??Also inhibits PDGFRa, c-Src and c-Kit (IC50=1.1, 5.4 and 12.5 nM respectively)2?as well as FGFR-mediated signaling (IC50<40 nM)3. Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models..4

What is the Ponatinib?

Ponatinib is , while it's Molecular Formula is C 29 H 27 F 3 N 6 O. Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively

What is the CAS number for Ponatinib?

The CAS number of Ponatinib is 943319-70-8.

What is Ponatinib (943319-70-8) used for?

Ponatinib (943319-70-8) is a highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well as the mutants T315I (IC50=2 nM), Q252H (IC50=0.44 nM), Y253F (IC50=0.3 nM), M351T (IC50=0.3 nM) and H396P (IC50=0.34 nM).1??Also inhibits PDGFRα, c-Src and c-Kit (IC50=1.1, 5.4 and 12.5 nM respectively)2?as well as FGFR-mediated signaling (IC50<40 nM)3. Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models..4

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Ponatinib

CasNo 943319-70-8
Purity 99%

Inquery

Manufacturer Supply Best Quality Ponatinib 943319-70-8 with Efficient Transportation

Molecular Formula: C₂₉H₂₇F₃N₆O
Molecular Weight: 532.568
PKA: 12.99±0.70(Predicted)
PSA： 65.77000
Density: 1.292 g/cm³
LogP: 4.40480

943319-70-8 Relevant articles

Preparation method of

-

Paragraph 0004; 0049; 0053-0056; 0058; 0062-0065, (2020/05/01)

The invention discloses a preparing meth...

Ppm Pd-catalyzed, Cu-free Sonogashira couplings in water using commercially available catalyst precursors

Jin, Bo,Gallou, Fabrice,Reilly, John,Lipshutz, Bruce H.

, p. 3481 - 3485 (2019/03/28)

A new catalyst that derives from commerc...

A drug treating chronic granulocytic leukemia method for the preparation of

-

, (2017/04/28)

The invention relates to a preparation m...

PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF

-

, (2016/12/26)

Methods are disclosed for making 3-(imid...

943319-70-8 Process route

: 694499-26-8
4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline

: C₁₇H₁₃N₃O₂*ClH

: 943319-70-8
ponatinib

Conditions

Conditions	Yield
With potassium tert-butylate; In 2-methyltetrahydrofuran; at 13 - 23 ℃; for 3h;

: 943320-50-1
3-iodo-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl) phenyl)benzamide

: 943320-61-4
3-ethynyl-imidazo[1,2-b]pyridazine

: 943319-70-8
ponatinib

Conditions

Conditions	Yield
With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;
With diisopropylamine; copper(l) chloride; In acetonitrile; for 10h; Reagent/catalyst; Solvent; Irradiation;

943319-70-8 Upstream products

943320-50-1
3-iodo-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl) phenyl)benzamide
943320-61-4
3-ethynyl-imidazo[1,2-b]pyridazine
694499-26-8
4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline
18087-73-5
3-bromo-imidazo[1,2-b]pyridazine