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- CasNo 480-37-5
- Purity 99%
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What is the Pinostrobin ?
Pinostrobin is , while it's Molecular Formula is C16H14O4. Used in Pharmaceutical Applications:
Pinostrobin is used as an anti-inflammatory agent for its ability to inhibit TNF-α and IL-1β production in RAW 264.7 macrophages and LPS-stimulated rats, potentially offering therapeutic benefits in conditions involving inflammation.
Used in Anticancer Applications:
Pinostrobin is used as an anticancer agent for its selective cytotoxicity against CCRF-CEM leukemia cells, making it a promising candidate for the development of targeted cancer therapies.
Used in Nutraceutical Applications:
Given its antioxidant properties, Pinostrobin can be used as a nutraceutical ingredient to support overall health and well-being by combating oxidative stress and promoting a balanced immune response.
Used in Drug Development:
Pinostrobin's diverse biological activities make it a valuable compound for further research and development in the pharmaceutical industry, potentially leading to the creation of new drugs for various health conditions.
What is the CAS number for Pinostrobin ?
The CAS number of Pinostrobin is 480-37-5.
More information of Pinostrobin 480-37-5 are:
|
Synonyms |
4H-1-Benzopyran-4-one,2,3-dihydro-5-hydroxy-7-methoxy-2-phenyl-, (S)-;Flavanone, 5-hydroxy-7-methoxy-(7CI,8CI);Pinostrobin (6CI);(-)-2S-Pinocembrin;(-)-Pinostrobin;5-Hydroxy-7-methoxyflavanone;7-Methylpinocembrin;Dihydrotectochrysin;Pinocembrin 7-methyl ether;Pinostrombin; |
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CAS?Number |
480-37-5 |
|
Molecular Formula |
C16H14O4 |
|
Molecular Weight |
270.285 |
|
Density |
1.284 g/cm3 |
|
Melting Point |
100 °C |
|
Boiling Point |
494.9 °C at 760 mmHg |
|
Flash Point |
188.8 °C |
|
HS CODE |
2932999099 |
|
PSA |
55.76000 |
|
LogP |
3.10730 |
|
Pka |
7.40±0.40(Predicted) |
What is Pinostrobin (480-37-5) used for?
Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM. Pinostrobin inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively). Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 μM) in a panel of eight cancer cell lines (IC50s = >30 μM).
InChI:InChI=1/C16H14O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-8,14,17H,9H2,1H3
Articles related to Pinostrobin:
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Article |
Source |
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Highly enantioselective and efficient synthesis of flavanones including pinostrobin through the rhodium-catalyzed asymmetric 1,4-addition |
Korenaga, Toshinobu,Hayashi, Keigo,Akaki, Yusuke,Maenishi, Ryota,Sakai, Takashi supporting information; experimental part, p. 2022 - 2025 (2011/06/28) |
|
Approaches to 2-substituted chroman-4-ones: Synthesis of (-)-pinostrobin |
Hodgetts, Kevin J. , p. 3763 - 3766 (2007/10/03) |
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