Clemizole hydrochloride


  • CasNo 1163-36-6
  • Purity 99%
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1.What is the Clemizole hydrochloride ?

Clemizole hydrochloride is a chemical compound with a variety of pharmacological properties, including antihistamine, antiviral, and anticonvulsant activities. It is known for its ability to inhibit Hepatitis C RNA replication, block histamine 1 receptors, and suppress the function of the nonstructural protein 4B (NS4B) in the virus.

Clemizole is an antihistamine that antagonizes the histamine 1 receptor at high nanomolar concentrations. It less potently blocks transient receptor potential canonical channel 5 (TRPC5; IC50 = 1.0-1.3 μM), with at least 6-fold selectivity for TRPC5 over other TRP channels. Clemizole also has hepatitis C antiviral action through inhibition of NS4B function, showing synergy with boceprevir , and it inhibits seizures in a zebrafish model of Dravet Syndrome.

2.What is the CAS number for Clemizole hydrochloride ?

The CAS number of Clemizole hydrochloride is 1163-36-6.

More information of Clemizole hydrochloride 1163-36-6 are:

CAS?Number

1163-36-6

Density

1.25 g/cm3

Melting Point

239-241°

Boiling Point

506.1 °C at 760 mmHg

Flash Point

259.9 °C

Vapor Pressure

2.29E-10mmHg at 25°C

PSA

21.06000

LogP

5.07370

3.What is the molecular formula of Clemizole hydrochloride ?

The chemical formula of?Clemizole hydrochloride is C19H20ClN3. HCl which containing 19 Carbon atoms,21 Hydrogen atoms,2 Chlorine atoms and 1 Nitrogen atoms,and the molecular weight, and the molecular weight of Clemizole hydrochloride is 362.302

4.What is Clemizole hydrochloride(1163-36-6)used for?

Clemizole hydrochloride is a chemical compound with a variety of pharmacological properties, including antihistamine, antiviral, and anticonvulsant activities. It is known for its ability to inhibit Hepatitis C RNA replication, block histamine 1 receptors, and suppress the function of the nonstructural protein 4B (NS4B) in the virus.

InChI:InChI=1/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H

Relevant articles related to Clemizole hydrochloride:

Article

Source

BENZIMIDAZOLE MODULATORS OF H1 RECEPTOR AND/OR NS4B PROTEIN ACTIVITY

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Page/Page column 31, (2010/11/03)

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