Volasertib (BI 6727)

CasNo 755038-65-4
Purity 99%

Inquery

Bulk supply high purity Volasertib (BI 6727) 755038-65-4, Paid sample available We supply high quality Volasertib (BI 6727) (CAS 755038-65-4), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the Volasertib (BI 6727) ?

Volasertib (BI 6727) is , while it's Molecular Formula is C₃₄H₅₀N₈O₃. Volasertib (BI 6727) is a highly potent Polo-like kinase (PLK) inhibitor.

What is the CAS number for Volasertib (BI 6727) ?

The CAS number of Volasertib (BI 6727) is 755038-65-4.

More information of Volasertib (BI 6727) 755038-65-4 are:

Synonyms	BI 6727; N-[trans-4-[4-(Cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxybenzamide
CAS?Number	755038-65-4
Molecular Formula	C₃₄H₅₀N₈O₃
Molecular Weight	618.823
Density	1.26
PSA	106.17000
LogP	4.73690
Pka	14.26±0.40(Predicted)

What is Volasertib (BI 6727) (755038-65-4) used for?

Volasertib (755038-65-4) is an extremely potent and selective inhibitor (IC50’s: Plk1= 0.87 nM, Plk2 = 5 nM, Plk3 = 56 nM) of Polo-like kinase 1, a critical controller of multiple essential steps of mitosis.1?It has shown efficacy in multiple solid xenograft tumors models1?and in clinical studies in patients with acute myeloid leukemia2. Volasertib has also been shown to potently inhibit BRD43?(Kd = 79 nM3, IC50’s bromodomains 1 and 2 of BRD4 = 300 and 770 nM respectively2).

Articles related to Volasertib (BI 6727):

Article

Source

PROCESS FOR MANUFACTURING DIHYDROPTERIDINONES AND INTERMEDIATES THEREOF

Page/Page column 25; 29-30, (2012/05/04)

CRYSTALLINE FORM OF A DIHYDROPTERIDIONE DERIVATIVE

Page/Page column 14-15, (2009/04/25)

How to get the best price on Volasertib (BI 6727)?

Hangzhou B&P Biotech Co,.Ltd is a quality supplier and manufacturer of Volasertib (BI 6727) . You can buy high quality, low price Volasertib (BI 6727) 755038-65-4 here. Contact us.